End-bridging is required for pol μ to efficiently promote repair of noncomplementary ends by nonhomologous end joining
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منابع مشابه
End-bridging is required for pol μ to efficiently promote repair of noncomplementary ends by nonhomologous end joining
DNA polymerase mu is a member of the mammalian pol X family and reduces deletion during chromosome break repair by nonhomologous end joining (NHEJ). This biological role is linked to pol mu's ability to promote NHEJ of ends with noncomplementary 3' overhangs, but questions remain regarding how it performs this role. We show here that synthesis by pol mu in this context is often rapid and, despi...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2008
ISSN: 1362-4962,0305-1048
DOI: 10.1093/nar/gkn164